News & Publications

External coverage and awards following PharmatrophiX, LM11A-31, and the emerging science of p75NTR modulation in Alzheimer’s disease.

May. 14, 2026

PharmatrophiX Selected for Landmark UCSF-led platform trial in rare neurodegenerative disease; Unveils New Data at Tau Global Conference

PharmatrophiX unveiled preclinical data at the Global Tau Conference further supporting evidence that LM11A-31 is a multi-action shield for the…

May. 7, 2026

Targeting Upstream Neurodegeneration: LM11A-31 in Alzheimer’s Disease and PSP

David Setboun, Pharm.D., MBA, CEO of PharmatrophiX, and Frank M. Longo, MD, PhD, Co-founder & Chairman, discuss LM11A-31’s upstream mechanism…

Feb. 25, 2026

A better Alzheimer’s drug?

Stanford Medicine profiles LM11A-31 as a synapse-protective approach to slowing neurodegeneration.

Dec. 2, 2025

p75 receptor modulation slows biomarkers and preserves visuospatial function

CTAD coverage reports p-tau217 and synaptic-proteome signals over 26 weeks.

Apr. 3, 2025

New drug candidate targeting synaptic resilience well tolerated in Alzheimer’s patients

NIA summarizes safety and biomarker findings supporting larger LM11A-31 trials.

May. 17, 2024

p75 neurotrophin receptor modulation in mild to moderate Alzheimer’s disease

The 26-week Phase 2a trial met its primary endpoint for safety and tolerability, with biomarker and imaging signals supporting further…

Oct. 24, 2023

Targeting Endogenous Mechanisms of Brain Resilience in Alzheimer’s Disease

JPAD review frames p75NTR as a tractable resilience pathway for neurodegeneration.

Feb. 11, 2016

Alzheimer’s from a New Angle

Dr. Frank Longo on hope, innovation, and a radical departure from traditional Alzheimer’s research

Sep. 16, 2015

Dr. Frank Longo wins inaugural Melvin R. Goodes Prize

ADDF recognized Longo’s pioneering Alzheimer’s drug discovery work.