Selected publications


Longo FM and Massa SM. (2013).Small Molecule Modulation of Neurotrophin Receptors for the Treatment
of Neurological Disease.Nature Reviews Drug Discovery, 12:507-525 [This article was invited by Nature
Reviews reflecting the pioneering role of Drs. Longo and Massa in the field. Cover and featured article].

P75 Receptor - Primary Articles

Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL and Longo
FM. (2006). Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J
Neurosci, 26:5288-5300.

Yang T, Knowles JK, Lu Q, Zhang H, Arancio 0, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller
GG, Xie Y, Massa SM, Longo FM. (2008). Small molecule, non-peptide p751igands inhibit Abeta-induced
neurodegeneration and synaptic impairment. PLoS ONE, 3:e3604.

Knowles JK, Rajadas J, Nguyen TV. Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T,
Longo FM. (2009). The p75 neurotrophin receptor promotes A~(1-42)-induced neuritic dystrophy in vitro
and in vivo. J Neurosci, 29:10627-10637.

Bernabeu RO and Longo FM. (2010). The p75 neurotrophin receptor is expressed by adult mouse dentate
progenitor cells and regulates neuronal and non-neuronal cell genesis. BMC Neurosci, 11:136.

Tep C, Lim TH, Ko PO, Getahun 5, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, and Yoon SO. (2013).
Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing
and functional recovery after spinal cord injury. J Neurosci, 33:397-410. PMCID: PMC3710149

KnowlesJK, SimmonsDA, NguyenT'1, Vander Griend L, XieY, ZhangH, YangT, PollakJ, ChangT, Arancio O,
Buckwalter M, Wyss-Coray T, Massa SM, Longo FM. (2013). A small molecule p75NTR ligand prevents
cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiology of Aging, PMID:

Shi J, Longo, FM and Massa SM. (2013). A small molecule p75NTR ligand protects neurogenesis after
traumatic brain injury. STEM CELLS, 31:2561-2574. PMID: 23940017

Nguyen TV. Shen L, Vander Griend L, Quach LN, Belichenko Np, Saw N, Yang T, Shamloo M, Wyss-Coray T,
Massa SM, Longo FM. (2014) Small Molecule p75NTR Ligands Reduce Pathological Phosphorylation and
Misfolding of Tau, Inflammatory Changes, Cholinergic Degeneration, and Cognitive Deficits in A~PPUS
Transgenic Mice. Journal of Alz Dis, 42:459-483.

Simmons DA, Knowles JK, Belichenko Np, Banerjee G, Finkle C, Massa SM, Longo FM. (2014). A Small
Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse
Models with Mid- to Late-Stage Disease Progression.PLoS One. Aug 25;9(8)


Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q. Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR. Neurotoxicology. 2014 Dec;45:81-90. doi: 10.1016/j.neuro.2014.09.005. Epub 2014 Sep 30. PubMed PMID: 25277379; PubMed Central PMCID: PMC4268328.


 Meeker RB, Poulton W, Clary G, Schriver M, Longo FM. Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis. Exp Neurol. 2016 Jan;275 Pt 1:182-98. doi: 10.1016/j.expneurol.2015.09.012. Epub 2015 Sep 28. PubMed PMID: 26424436; PubMed Central PMCID: PMC4688079.


Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum Mol Genet. 2016 Nov 15;25(22):4920-4938. doi: 10.1093/hmg/ddw316.
PubMed PMID: 28171570; PubMed Central PMCID: PMC5418739.


Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM,  Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J Neurosci. 2016 Sep 28;36(39):10116-27. doi:  10.1523/JNEUROSCI.4597-14.2016. Epub 2016 Sep 28. PubMed PMID: 27683907; PubMed Central PMCID: PMC5039257.


James ML, Belichenko NP, Shuhendler AJ, Hoehne A, Andrews LE, Condon C, Nguyen TV, Reiser V, Jones P, Trigg W, Rao J, Gambhir SS, Longo FM. [(18)F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease. Theranostics. 2017 Mar 24;7(6):1422-1436. doi: 10.7150/thno.17666. eCollection 2017. PubMed PMID: 28529627; PubMed Central PMCID: PMC5436503.


Haefeli J, Ferguson AR, Bingham D, Orr A, Won SJ, Lam TI, Shi J, Hawley S, Liu J, Swanson RA, Massa SM. A data-driven approach for evaluating multi-modal therapy in traumatic brain injury. Sci Rep. 2017 Feb 16;7:42474. doi:
10.1038/srep42474. PubMed PMID: 28205533; PubMed Central PMCID: PMC5311970.


Simmons DA, James ML, Belichenko NP, Semaan S, Condon C, Kuan J, Shuhendler AJ, Miao Z, Chin FT, Longo FM. TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease:
preclinical evidence with the p75NTR ligand LM11A-31. Hum Mol Genet. 2018 Aug 15;27(16):2893-2912. doi: 10.1093/hmg/ddy202. PubMed PMID: 29860333; PubMed Central PMCID: PMC6077813.


Elshaer SL, Alwhaibi A, Mohamed R, Lemtalsi T, Coucha M, Longo FM, El-Remessy AB. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500. doi: 10.1007/s00125-019-4885-2. Epub 2019 May 9. PubMed PMID: 31073629.


Xie Y, Meeker RB, Massa SM, Longo FM. Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.  Sci Rep. 2019 Mar 27;9(1):5273. doi: 10.1038/s41598-019-41654-8. PubMed PMID: 30918278; PubMed Central PMCID: PMC6437186.


P75 Receptor - Abstract - First Place Award

First Place Award - European Commission Imaging of Neuroinflammation in Neurodegenerative Disease:
Symposium on Microglia Imaging and Biology - University of Manchester April 2014. Dr Michelle James
(Stanford University): [18F]GE-180-PET/MRI and ex vivo autoradiography detects reduced microglia activation
after LMllA-31 therapy in a mouse model of Alzheimer's disease.

Trk Receptor - Primary Articles

Massa SM, YangT XieY, ShiJ, BilgenM, Joyce IN, NehamaD, Rajadas J and Longo FM. (2010). Small molecule
BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest, 120:

Schmid DA, Yang 1, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM. (2012).A TrkB
small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a
mouse model of Rett syndrome. J Neurosci,32:1803-1810.


Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B,

Jing D, Massa SM, Longo FM, Buckwalter MS. (2012). Delayed administration of a small molecule TrkB ligand

promotes recovery after hypoxic-ischemic stroke. Stroke 43:1918-1924.


Simmons DA, Belichenko Np, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, and Longo
FM. (2013). A small molecule TrkB ligand reduces motor impairment and neuropathology in R6-2 and BACHD
mouse models of Huntington's Disease. J Neurosci, 33:18712-18727.


Kron M, Lang M, Adams I, Sceniak M, Longo FM, and Katz DM (2014). A BDNF loop domain mimetic acutely
reverses spontaneous apneas and respiratory abnormalities during behavioral arousal in a mouse model of
Rett syndrome. Dis Model Mech, 7:1047-1055.


Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM,  Ron D. The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry. 2016 Mar 15;79(6):463-73. doi: 10.1016/j.biopsych.2015.06.007.
Epub 2015 Jun 12. PubMed PMID: 26204799; PubMed Central PMCID: PMC4676961.

Li W, Bellot-Saez A, Phillips ML, Yang T, Longo FM, Pozzo-Miller L. A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice. Dis Model Mech. 2017 Jul 1;10(7):837-845.
doi: 10.1242/dmm.029959. PubMed PMID: 28679669; PubMed Central PMCID: PMC5536912.


Gu F, Parada I, Yang T, Longo FM, Prince DA. Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons. Neurobiol Dis. 2018 May;113:45-58. doi: 10.1016/j.nbd.2018.01.018. Epub 2018 Feb 2. PubMed PMID: 29408225.


Ali Shariati M, Kumar V, Yang T, Chakraborty C, Barres BA, Longo FM, Liao YJ.  A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy. Curr Eye Res. 2018 Dec;43(12):1489-1499. doi: 10.1080/02713683.2018.1508726. Epub 2018 Oct 1.
PubMed PMID: 30273053.